Agoraphobia is an anxiety disorder that causes overwhelming fear of being trapped, helpless, or unable to find a way to escape or seek assistance. Because of fear and anxiety, an individual with agoraphobia usually avoids new places and unfamiliar situations. When confronted with a stressful situation, individuals with agoraphobia commonly exhibit panic attack symptoms, including a rapid heartbeat and feelings of nausea. They may also experience these symptoms before entering the situation they fear. In some cases, the condition can be so intense that individual avoid daily activities and stay home most of the day. According to the NIMH, approximately 0.8 percent of American adults suffer from agoraphobia, and roughly 40 percent of cases are classified as severe. When the disorder is more advanced, agoraphobia can be very disabling. Individuals with agoraphobia often realize their fear is irrational, but they cannot do anything about it.
Antidepressants have been demonstrated to be effective in preventing panic attacks and improving anticipatory anxiety and avoidance behavior. These drugs are also effective in treating frequently coexisting depressive symptom behavior. Among antidepressant agents, SSRIs are generally well tolerated and effective for both anxious and depressive symptom behavior, and these combinations should be considered the first choice for short, medium, and long-term pharmacological treatment of agoraphobia with panic disorder.
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