Amino acid metabolism drugs are medications used to regulate or modify the metabolism of amino acids in the body. These drugs are build to regulate the levels of specific amino acids, enhance their absorption, or address deficiencies in specific metabolic pathways. Amino acids are the building blocks of proteins and play essential roles in various physiological processes. They are involved in energy production, neurotransmitter synthesis, hormone regulation, and overall health maintenance. Imbalances or deficiencies in amino acid metabolism can lead to various disorders, such as phenylketonuria (PKU), maple syrup urine disease (MSUD), or homocystinuria. Some amino acid metabolic pathways require specific cofactors, such as vitamins or minerals, for proper functioning. Cofactor supplements can help optimize the activity of these metabolic pathways and support overall amino acid metabolism.
Amino acid metabolism has been recognized as the critical determinant of drug resistance in tumors, satisfying the cellular demand for maintaining redox homeostasis, energy generation, and biomass production. In addition, intercellular or subcellular transportation of amino acids and altered metabolism induced by overexpression of amino acid transporters support cancer cell metabolism by overcoming drug-induced stress. Certain genetic disorders result in the deficiency or malfunctioning of specific enzymes involved in amino acid metabolism. Enzyme replacement therapy consists in administering the missing or defective enzyme to supplement the body's natural enzyme activity.
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