Overview


According to FutureWise analysis, the liquid chromatography mass spectrometry market in 2023 was US$5.71 billion, and is expected to reach US$14.36 billion by 2031 at a CAGR of 12.22%. The remarkable growth in the analytical techniques market is primarily attributed to the increasing demand for high-throughput and precise methodologies within the pharmaceutical, biotechnology, and clinical research sectors. Liquid chromatography mass spectrometry (LC-MS) has emerged as the gold standard in drug development, biomarker discovery, and toxicology studies, thanks to its exceptional precision and sensitivity. Furthermore, continuous technological advancements are broadening the scope of LC-MS applications, extending into areas such as environmental testing and food safety.

The term "liquid chromatography" refers to a research method that helps users separate and uniquely identify chemicals, nucleic acids, and proteins in a given combination. The method is based on interactions between the sample in stationary and mobile phases. Another analytical method that offers determination of the mass-to-charge ratio of ions in the form of a mass spectrum is known as mass spectrometry.

For toxicological applications in the clinical laboratory, LC-MS is a potent tool. An LC-MS is mostly used in toxicology laboratories for broad-spectrum drug screening and drug confirmation testing after an immunoassay screen. It is also utilized to separate, identify, and quantify both known and unidentified substances, as well as to clarify the structure and chemical characteristics of various molecules. It offers improved sensitivity and selectivity in the trace analysis of compounds having several components and is especially helpful for analysing tiny molecules. The increase in global energy and construction-related project activity is one of the major drivers of the liquid chromatography-mass spectrometry market's expansion. The global population's growing awareness of the negative impacts of environmental pollution and the expansion of environmental testing in India as a result of government initiatives both contribute to the market's rapid expansion. The market is also impacted by the spike in demand for the construction of waste infrastructure and the implementation of strict rules, such as the sustainable transformation of environmental policies. Moreover, the market for liquid chromatography-mass spectrometry is favourably impacted by rising levels of air and water pollution, an increase in the number of vehicles powered by non-renewable resources, and expanding industrial operations.

FutureWise Market Research has published a report that provides an insightful analysis of Global Liquid Chromatography Mass Spectrometry Market trends that are affecting the overall market growth. This report will provide a detailed analysis of market share, regional insights, and competitor analysis that includes stature of key manufacturers operational in this industry. By the end of the forecast period FutureWise research analysts projects that Global Liquid Chromatography Mass Spectrometry Market will experience a significant growth. According to the analysis done, this report will help understand the information referring to the total valuation held by this industry. Additionally, this report will help in understanding the growth opportunities held by various segments of this market, further assist in making better strategic and expansion decisions by key stakeholders of an organization.

  • Danaher Corporation
  • PerkinElmer, Inc.
  • Waters Corporation
  • Bruker Corporation
  • Thermo Fisher Scientific Inc.
  • Agilent Technologies, Inc.
  • Shimadzu Corporation
  • JEOL Ltd.
  • Newomics, Inc.

Recent developments by key players in the Global Liquid Chromatography Mass Spectrometry Market:

Agilent Technologies, Inc.

  • Launch of the InfinityLab Pro iQ Series at ASMS 2025: These compact, intelligent LC–MS systems (Pro iQ & Pro iQ Plus) support the analysis of small molecules, peptides, and proteins, offering increased automation and enhanced sustainability, certified by My Green Lab.
  • Streamlined laboratory workflows: Launched the 8850 GC, now compatible with single and triple quadrupole mass spectrometry. This model features a 20% increase in sensitivity, 30–45% lower power consumption, and a high throughput of approximately 100 samples per day, highlighting Agilent’s dedication to sustainable lab efficiency.
  • In November 2024, the organization will be restructured into market-focused segments: Life Sciences & Diagnostics, Applied Markets, and CrossLab. This change is designed to better meet customer needs and accelerate workflow innovation.

Thermo Fisher Scientific

  • The Q Exactive HF-X Orbitrap MS is set to launch in September 2024. It provides high-resolution analysis, making it ideal for proteomics and clinical research.
  • Thermo Stellar MS was introduced in June 2024. It is designed for translational 'omics, providing rapid throughput, increased sensitivity, and ease of use.
  • Key acquisitions and partnerships include the acquisition of PharmaFluidics’ μPAC chromatographic technology and Olink in October 2023, as well as a partnership with Pfizer on cancer testing platforms, all of which enhance LC-MS capabilities.

Waters Corporation

  • The Alliance iS HPLC System, launched in April 2024, features automated error detection that reduces failure-driven interventions by approximately 40%, making it explicitly optimized for bioseparation laboratories.
  • Enhancements to the BioAccord LC–MS system include the release of Intact Mass software on waters_connect, along with new Premier Protein BEH C4 300Å columns, which simplify the analysis of biotherapeutics.
  • In June 2021, Newomics and Thermo Fisher Scientific announced the development of innovative methods for LC-MS analysis of natural protein complexes.
  • In March 2022, Bruker Corporation introduced a revolutionary LC-MS platform for drug discovery in the pharmaceutical and biopharmaceutical industries, as well as educational institutions. This platform was developed in collaboration with Newomics Inc., a biotechnology company that specializes in selling mass spectrometry solutions for molecular identification.

The growing use of liquid chromatography mass spectrometry (LC-MS) in several applications, including proteomics, metabolomics, drug discovery, and environmental testing, is among the key factors driving the market. The market expansion is primarily credited to improvements in LC-MS technology and the rise in demand for customised medication. The popularity of LC-MS applications for proteomics and metabolomics is growing as a result of these technologies' superior sensitivity and accuracy while analysing complicated biological materials. Drug development, understanding biological processes, and illness diagnosis and therapy all make use of these applications. The need for LC-MS equipment is also being boosted by the expanding research and development efforts in the fields of proteomics and metabolomics. Also, the need for LC-MS in environmental testing is being driven by the rising environmental concerns and laws. Pollutants and contaminants in soil, water, and air may be found and measured with the use of LC-MS. 

The expensive cost of LC-MS equipment and the scarcity of qualified personnel to use these instruments can limit market expansion. Moreover, the adoption of LC-MS in small and medium-sized laboratories may be constrained by the complexity of the LC-MS workflow and the requirement for routine maintenance.

By Type

  • Quadruple
    • Single Quadruple LC-MS
    • Triple Quadruple LC-MS
  • Ion Trap LC-MS
  • Time of Flight LC-MS

By Sensitivity

  • Nano Flow
    • Standalone
    • Bench-top
  • Micro Flow
    • Standalone
    • Bench-top
  • High Flow
    • Standalone
    • Bench-top

By End User

  • Hospital and Research Laboratories
    • Large Size Companies
    • Mid Size Companies
    • Small Companies
  • Biotechnology and Pharmaceutical Industry
    • Public
    • Private
  • Academic & Research Institutes
  • Others

By Region

  • North America
  • Europe
  • Asia-Pacific
  • Latin America
  • Middle East and Africa

This market research report also emphasis on factors affecting the growth rate in various regions listed above. A deep-down analysis of region will also be provided in the final version of this market which is based on conclusion of primary interviews and secondary data point gathered during the process.

By region, the market is segmented into North America, Latin America, Europe, Asia-Pacific, and Middle East & Africa. North America registered highest share in the market in 2022. North America is also the biggest market, with 39.9% share in 2022. The mass spectrometry industry in North America is being driven by the growing funding for research and government initiatives in the United States, the extensive use of mass spectrometry in the metabolomics and petroleum industries, and CFI support for mass spectrometry studies in Canada. Analytical methods are being promoted by regulatory agencies in the US, such as the FDA, to ensure that pharmaceutical products released to the market adhere to quality standards. By type; quadruple holds 61.7% share in the global market, followed by Trap LC-MS 26.3%, and time of flight LC-MS 12%. By end-user, the biotech & pharma segment is the highest market share, holding segment 48.9%. The growth of the pharmaceutical industry, rising government and corporate financing for pharmaceutical research, and the advent of tight laws and guidelines for drug development and safety are just a few of the factors that are propelling the market's expansion in regard to the end-user segment.

  • Tier 1 players- established companies in the market with major market share
  • Tier 2 players
  • New Entrants
  • Emerging players which are growing rapidly

  • Growth prospects
  • SWOT analysis
  • Key trends
  • Key data points affecting market growth

  • To provide with an exhaustive analysis on the Global Liquid Chromatography Mass Spectrometry Market By Type, By Sensitivity, By End User and By Region.
  • To cater comprehensive insights on factors such as drivers, restraints, trends, opportunity, and additionally segmental and regional factors impacting market growth.
  • To evaluate current market trends and forecast micro-markets and the overall market projections which are represented in the format of data-sets and ppt.
  • To predict the market size, in key regions— North America, Europe, Asia Pacific, Latin America and Middle East and Africa.
  • To provide information on competitors which includes landscape mapping, technological advancements, R&D spending, news concerning strategic alliances, and new product launches

  • We have a flexible delivery model and you can suggest changes in the scope/table of content as per your requirement
  • The customization Mobility Care offered are free of charge with purchase of any license of the report
  • You can directly share your requirements/changes to the current table of content to: sales@futurewiseresearch.com

 

Table of Contents


  • 1.   Market Introduction
    •   1. Objectives of the Study
        2. Market Definition
        3. Market Scope
         3.1. Years Considered for the Study
         3.2. Market Covered
        4. Currency
        5. Limitations
        6. Stakeholders
  • 2.   Research Methodology
    •   1. Research Data
         1.1. Secondary Data
          1.1.1. Key Data from Secondary Sources
         1.2. Primary Data
          1.2.1. Key Data from Primary Sources
        2. Market Size Estimation
        3. Market Breakdown and Data Triangulation
        4. Assumptions for the Study
  • 3.   Executive Summary
    •   1. Market Outlook
        2. Segment Outlook
        3. Competitive Insights
  • 4.   Liquid Chromatography Mass Spectrometry Market Variables, Trends and Scope
    •   1. Market Lineage Outlook
        2. Penetration and Growth Prospect Mapping
        3. Industry Value Chain Analysis
        4. Cost Analysis Breakdown
        5. Technology Overview
        6. Regulatory Framework
         6.1. Reimbursement Framework
         6.2. Standards and Compliances

  • 5.   Market Overview
    •   1. Market Dynamics
         1.1. Market Driver Analysis
          1.1.1. Increasing focus of Liquid Chromatography Mass Spectrometry Market Companies on Brand Protection
          1.1.2. Untapped Opportunities in Emerging Regions
         1.2. Market Restraint Analysis
          1.2.1. High Cost Associated with Implementation of Predictive Analysis
         1.3. Industry Challenges
          1.3.1. Presence of Ambiguous Regulatory Framework
  • 6.   Liquid Chromatography Mass Spectrometry Market Analysis Tools
    •   1. Industry Analysis - Porter’s
         1.1. Supplier Power
         1.2. Buyer Power
         1.3. Substitution Threat
         1.4. Threat from New Entrants
         1.5. Competitive Rivalry
        2. Pestel Analysis
         2.1. Political Landscape
         2.2. Environmental Landscape
         2.3. Social Landscape
         2.4. Technology Landscape
         2.5. Legal Landscape
        3. Major Deals And Strategic Alliances Analysis
         3.1. Joint Ventures
         3.2. Mergers and Acquisitions
         3.3. Licensing and Partnership
         3.4. Technology Collaborations
         3.5. Strategic Divestments
        4. Market Entry Strategies
        5. Case Studies
  • 7.   Liquid Chromatography Mass Spectrometry Market, By Type Historical Analysis and Forecast 2025-2033 (USD Million)
    •   1. Quadruple
         1.1. Single Quadruple LC-MS
         1.2. Triple Quadruple LC-MS
        2. Ion Trap LC-MS
        3. Time of Flight LC-MS

  • 8.   Liquid Chromatography Mass Spectrometry Market, By Sensitivity Historical Analysis and Forecast 2025-2033 (USD Million)
    •   1. Nano Flow
         1.1. Standalone
         1.2. Bench-top
        2. Micro Flow
         2.1. Standalone
         2.2. Bench-top
        3. High Flow
         3.1. Standalone
         3.2. Bench-top

  • 9.   Liquid Chromatography Mass Spectrometry Market, By End User Historical Analysis and Forecast 2025-2033 (USD Million)
    •   1. Hospital and Research Laboratories
         1.1. Large Size Companies
         1.2. Mid Size Companies
         1.3. Small Companies
        2. Biotechnology and Pharmaceutical Industry
         2.1. Public
         2.2. Private
        3. Academic & Research Institutes
        4. Others

  • 10.   North America Liquid Chromatography Mass Spectrometry Market Analysis 2018-2024 and Forecast 2025-2033 (USD Million)
    •   1. Introduction
        2. Historical Market Size (USD Million) Analysis By Country, 2018-2024
         2.1. U.S.A
         2.2. Canada
         2.3. Mexico
        3. Market Size (USD Million) Forecast for North America 2025-2033

  • 11.   Latin America Liquid Chromatography Mass Spectrometry Market Analysis 2018-2024 and Forecast 2025-2033 (USD Million)
    •   1. Introduction
        2. Historical Market Size (USD Million) Analysis By Country, 2018-2024
         2.1. Brazil
         2.2. Venezuela
         2.3. Argentina
         2.4. Rest of Latin America
        3. Market Size (USD Million) Forecast for Latin America 2025-2033

  • 12.   Europe Liquid Chromatography Mass Spectrometry Market Analysis 2018-2024 and Forecast 2025-2033 (USD Million)
    •   1. Introduction
        2. Historical Market Size (USD Million) Analysis By Country, 2018-2024
         2.1. Germany
         2.2. U.K
         2.3. France
         2.4. Italy
         2.5. Spain
         2.6. Russia
         2.7. Poland
         2.8. Rest of Europe
        3. Market Size (USD Million) Forecast for Europe 2025-2033

  • 13.   Asia Pacific Liquid Chromatography Mass Spectrometry Market Analysis 2018-2024 and Forecast 2025-2033 (USD Million)
    •   1. Introduction
        2. Historical Market Size (USD Million) Analysis By Country, 2018-2024
         2.1. Japan
         2.2. China
         2.3. India
         2.4. Australia and New Zealand
         2.5. ASEAN
         2.6. Rest of Asia Pacific
        3. Market Size (USD Million) Forecast for Asia Pacific 2025-2033

  • 14.   Middle East and Africa Market Analysis 2018-2024 and Forecast 2025-2033 (USD Million)
    •   1. Introduction
        2. Historical Market Size (USD Million) Analysis By Country, 2018-2024
         2.1. GCC
         2.2. Israel
         2.3. South Africa
         2.4. Rest of MEA
        3. Market Size (USD Million) Forecast for MEA 2025-2033

  • 15.   Market Share Analysis and Competitive Landscape
    •   1. Global Landscape - Key Players, Revenue and Presence
        2. Global Share Analysis - Key Players (Tier 1, Tier 2, Tier 3)
        3. Global Emerging Companies
        4. North America - Market Share Analysis and Key Regional Players
        5. Europe - Market Share Analysis and Key Regional Players
        6. Asia Pacific - Market Share Analysis and Key Regional Players
        7. Global Key Player - Growth Matrix
  • 16.   Company Profiles (Competition Dashboard, Competitors Deep Dive, Products Offered and Financial Layouts)
    •   1. Danaher Corporation
         1.1. Company Overview
         1.2. Product Portfolio
         1.3. SWOT Analysis
         1.4. Financial Overview
         1.5. Strategic Overview
        2. PerkinElmer, Inc.
         2.1. Company Overview
         2.2. Product Portfolio
         2.3. SWOT Analysis
         2.4. Financial Overview
         2.5. Strategic Overview
        3. Waters Corporation
         3.1. Company Overview
         3.2. Product Portfolio
         3.3. SWOT Analysis
         3.4. Financial Overview
         3.5. Strategic Overview
        4. Bruker Corporation
         4.1. Company Overview
         4.2. Product Portfolio
         4.3. SWOT Analysis
         4.4. Financial Overview
         4.5. Strategic Overview
        5. Thermo Fisher Scientific Inc.
         5.1. Company Overview
         5.2. Product Portfolio
         5.3. SWOT Analysis
         5.4. Financial Overview
         5.5. Strategic Overview
        6. Agilent Technologies, Inc.
         6.1. Company Overview
         6.2. Product Portfolio
         6.3. SWOT Analysis
         6.4. Financial Overview
         6.5. Strategic Overview
        7. Shimadzu Corporation
         7.1. Company Overview
         7.2. Product Portfolio
         7.3. SWOT Analysis
         7.4. Financial Overview
         7.5. Strategic Overview
        8. JEOL Ltd.
         8.1. Company Overview
         8.2. Product Portfolio
         8.3. SWOT Analysis
         8.4. Financial Overview
         8.5. Strategic Overview
        9. Newomics, Inc.
         9.1. Company Overview
         9.2. Product Portfolio
         9.3. SWOT Analysis
         9.4. Financial Overview
         9.5. Strategic Overview

  • 17.   Pre and Post COVID-19 Impact
    •   1. Positive influence on the healthcare industry
        2. The financial disruption of the manufacturing sector
        3. Impact of COVID-19 on emerging companies
        4. Significant mandates in the regulations initiated by healthcare
                  administrations
        5. The overall economic slowdown of the developing and developed nations

  • 18.   FutureWise SME Key Takeaway Points for Client

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