Overview


According to FutureWise analysis the market for mixed-mode chromatography resin in 2023 is US$ 0.11 billion, and is expected to reach US$ 0.2 billion by 2031 at a CAGR of 7.32%.

Mixed-mode chromatography is a type of chromatography that utilizes both ion exchange and hydrophobic interactions to separate and purify biological molecules. The mixed-mode chromatography resin is a type of resin that incorporates both ion-exchange and hydrophobic properties in its beads, allowing it to perform both ion-exchange and hydrophobic interaction chromatography. This type of chromatography has become increasingly popular due to its ability to purify proteins and other biological molecules that may be difficult to separate using traditional ion-exchange or hydrophobic interaction chromatography alone.

Leading pharmaceutical companies' continued efforts to create new drugs, notably to find a treatment for contagious diseases like Ebola, Zika, and H1N1, have increased demand in the market. The majority of biopharmaceutical drug discovery and development efforts are currently outsourced by large, well-established pharmaceutical and biopharma companies. To ensure safety and quality, companies use chromatography when creating and manufacturing biological pharmaceutical tools. Chromatography is currently utilised as a valuable technology in the field of pharmaceutical, chemical, biochemistry, and environmental science for the purification, separation, and analysis of substances present in complicated mixtures.

FutureWise Market Research has published a report that provides an insightful analysis of Mixed-mode Chromatography Resin Market trends that are affecting the overall market growth. This report will provide a detailed analysis of market share, regional insights, and competitor analysis that includes stature of key manufacturers operational in this industry. By the end of the forecast period FutureWise research analysts’ projects that Mixed-mode Chromatography Resin Market will experience a significant growth. According to the analysis done, this report will help understand the information referring to the total valuation held by this industry. Additionally, this report will help in understanding the growth opportunities held by various segments of this market, further assist in making better strategic and expansion decisions by key stakeholders of an organization.

  • GE Healthcare Lifesciences
  • Merck KGaA
  • Tosoh Corp
  • Purolite Corp
  • Danaher Corp
  • Bio-Rad Labs

(Note: The list of the major players will be updated with the latest market scenario and trends)

Recent developments by key players in Mixed-mode Chromatography Resin Market:

In June 2022, A supplier of chromatographic solutions, Tosoh Bioscience GmbH, introduced a range of SkillPak 50 and 200 pre-packed columns. These columns are used to produce oligonucleotides, viruses, ADCs, monoclonal antibodies, and antibody fragments.

The market for mixed mode chromatography resins is expected to grow due to increasing demand for faster, more efficient, high-quality and cost-effective purification processes in the biopharmaceutical industry. The industry's growing focus on the production of monoclonal antibodies and other biologics is driving the demand for mixed mode chromatography resins. Factors such as the increasing adoption of single-use chromatography systems and the growing demand for the need of vaccines are also expected to drive market growth. However, factors such as high costs associated with the development and commercialization of mixed mode chromatography resins, lack of skilled professionals and a limited number of players in the market may act as barriers to market growth. Henceforth, the mixed mode chromatography resin market is expected to grow in the coming years, driven by increasing demand from the biopharmaceutical and biotechnology industry.

By Type

  • Ion Exchange-Hydrophobic Type
  • Hydroxyapatite Type
  • Others

By Application

  • Antibodies Production 
  • Vaccine Production 
  • Non-antibody Proteins
  • Antibody-drug conjugate
  • Separation of low molecular weight impurities

By Region

  • North America
  • Europe 
  • Asia-Pacific
  • Latin America
  • Middle East and Africa

This market research report also emphasis on factors affecting the growth rate in various regions listed above. A deep-down analysis of region will also be provided in the final version of this market which is based on conclusion of primary interviews and secondary data point gathered during the process.

By region, the market is segmented into North America, Latin America, Europe, Asia-Pacific, and Middle East & Africa. North America registered highest share in the market in 2022 due to substantial government investment in R&D activities and as a result of the key players who have a firm foothold in the area. Despite this, management companies, organisations, outside managers, and so forth are focusing their efforts on creating customer-driven products that will also contribute to the growth in this sector. The Mixed-mode Chromatography Resin market is likely to experience considerable growth due to factors such as rising interest, increased pay, cutting-edge innovation, and equipment, as well as initiatives to draw attention to the need in the region. In the type segment, ion-exchange hydrophobic holds the highest market share of 66% in the global market in 2022. Protein molecules are separated and purified using ion exchange-hydrophobic interactions based on how hydrophobic they are. This method of mixed-mode chromatography successfully eliminates contaminants while maintaining the protein's biological function.


  • Tier 1 players- established companies in the market with a major market share
  • Tier 2 players
  • Emerging players which are growing rapidly
  • New Entrants

  • Growth prospects
  • SWOT analysis
  • Key trends
  • Key data-points affecting market growth

  • To provide with an exhaustive analysis on the Mixed-mode Chromatography Resin Market By Type, By Application and By Region
  •  To cater comprehensive information on factors impacting market growth (drivers, restraints, opportunities, and industry-specific restraints)
  • To evaluate and forecast micro-markets and the overall market
  • To predict the market size, in key regions— North America, Europe, Asia Pacific, Latin America and Middle East and Africa
  • To record and evaluate competitive landscape mapping- product launches, technological advan Terumoents, mergers and expansions

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  • The customization services offered are free of charge with purchase of any license of the report.
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Table of Contents


  • 1.   Market Introduction
    •   1. Objectives of the Study
        2. Market Definition
        3. Market Scope
         3.1. Years Considered for the Study
         3.2. Market Covered
        4. Currency
        5. Limitations
        6. Stakeholders
  • 2.   Research Methodology
    •   1. Research Data
         1.1. Secondary Data
          1.1.1. Key Data from Secondary Sources
         1.2. Primary Data
          1.2.1. Key Data from Primary Sources
        2. Market Size Estimation
        3. Market Breakdown and Data Triangulation
        4. Assumptions for the Study
  • 3.   Executive Summary
    •   1. Market Outlook
        2. Segment Outlook
        3. Competitive Insights
  • 4.   Mixed-mode Chromatography Resin Market Variables, Trends and Scope

    •        1. Market Lineage Outlook
        2. Penetration and Growth Prospect Mapping
        3. Industry Value Chain Analysis
        4. Cost Analysis Breakdown
        5. Technology Overview
        6. Regulatory Framework
         6.1. Reimbursement Framework
         6.2. Standards and Compliances

  • 5.   Mixed-mode Chromatography Resin Market Overview
    •   1. Market Dynamics
         1.1. Market Driver Analysis
          1.1.1. Increasing focus of Mixed-mode Chromatography Resin Companies on Brand Protection
          1.1.2. Untapped Opportunities in Emerging Regions
         1.2. Market Restraint Analysis
          1.2.1. High Cost Associated with Implementation of Predictive Analysis
         1.3. Industry Challenges
          1.3.1. Presence of Ambiguous Regulatory Framework
  • 6.   Mixed-mode Chromatography Resin Market Analysis Tools
    •   1. Industry Analysis - Porter’s
         1.1. Supplier Power
         1.2. Buyer Power
         1.3. Substitution Threat
         1.4. Threat from New Entrants
         1.5. Competitive Rivalry
        2. Pestel Analysis
         2.1. Political Landscape
         2.2. Environmental Landscape
         2.3. Social Landscape
         2.4. Technology Landscape
         2.5. Legal Landscape
        3. Major Deals And Strategic Alliances Analysis
         3.1. Joint Ventures
         3.2. Mergers and Acquisitions
         3.3. Licensing and Partnership
         3.4. Technology Collaborations
         3.5. Strategic Divestments
        4. Market Entry Strategies
        5. Case Studies
  • 7.   Mixed-mode Chromatography Resin Market, By Type Historical Analysis and Forecast 2025-2033 (USD Million)

    •   1. Ion Exchange-Hydrophobic Type
        2. Hydroxyapatite Type
        3. Others

  • 8.   Mixed-mode Chromatography Resin Market, By Application Historical Analysis and Forecast 2025-2033 (USD Million)

    •   1. Antibodies Production
        2. Vaccine Production
        3. Non-Antibody Proteins
        4. Antibody-drug conjugate
        5. Separation of low molecular weight impurities

  • 9.   North America Mixed-mode Chromatography Resin Market Analysis 2018-2024 and Forecast 2025-2033 (USD Million)

    •   1. Introduction
        2. Historical Market Size (USD Million) Analysis By Country, 2018-2024
         2.1. U.S.A
         2.2. Canada
         2.3. Mexico
        3. Market Size (USD Million) Forecast for North America 2025-2033

  • 10.   Latin America Mixed-mode Chromatography Resin Market Analysis 2018-2024 and Forecast 2025-2033 (USD Million)

    •   1. Introduction
        2. Historical Market Size (USD Million) Analysis By Country, 2018-2024
         2.1. Brazil
         2.2. Venezuela
         2.3. Argentina
         2.4. Rest of Latin America
        3. Market Size (USD Million) Forecast for Latin America 2025-2033

  • 11.   Europe Mixed-mode Chromatography Resin Market Analysis 2018-2024 and Forecast 2025-2033 (USD Million)

    •   1. Introduction
        2. Historical Market Size (USD Million) Analysis By Country, 2018-2024
         2.1. Germany
         2.2. U.K
         2.3. France
         2.4. Italy
         2.5. Spain
         2.6. Russia
         2.7. Poland
         2.8. Rest of Europe
        3. Market Size (USD Million) Forecast for Europe 2025-2033

  • 12.   Asia Pacific Mixed-mode Chromatography Resin Market Analysis 2018-2024 and Forecast 2025-2033 (USD Million)

    •   1. Introduction
        2. Historical Market Size (USD Million) Analysis By Country, 2018-2024
         2.1. Japan
         2.2. China
         2.3. India
         2.4. Australia and New Zealand
         2.5. ASEAN
         2.6. Rest of Asia Pacific
        3. Market Size (USD Million) Forecast for Asia Pacific 2025-2033

  • 13.   Middle East and Africa Market Analysis 2018-2024 and Forecast 2025-2033 (USD Million)

    •   1. Introduction
        2. Historical Market Size (USD Million) Analysis By Country, 2018-2024
         2.1. GCC
         2.2. Israel
         2.3. South Africa
         2.4. Rest of MEA
        3. Market Size (USD Million) Forecast for MEA 2025-2033

  • 14.   Market Share Analysis and Competitive Landscape
    •   1. Global Landscape - Key Players, Revenue and Presence
        2. Global Share Analysis - Key Players (Tier 1, Tier 2, Tier 3)
        3. Global Emerging Companies
        4. North America - Market Share Analysis and Key Regional Players
        5. Europe - Market Share Analysis and Key Regional Players
        6. Asia Pacific - Market Share Analysis and Key Regional Players
        7. Global Key Player - Growth Matrix
  • 15.   Company Profiles (Competition Dashboard, Competitors Deep Dive, Product Connected Devices and Disease Indication Portfolio, Financial Layouts)

    •   1. GE Healthcare Lifesciences
         1.1. Company Overview
         1.2. Product Portfolio
         1.3. SWOT Analysis
         1.4. Financial Overview
         1.5. Strategic Overview
        2. Merck KGaA
         2.1. Company Overview
         2.2. Product Portfolio
         2.3. SWOT Analysis
         2.4. Financial Overview
         2.5. Strategic Overview
        3. Tosoh Corp
         3.1. Company Overview
         3.2. Product Portfolio
         3.3. SWOT Analysis
         3.4. Financial Overview
         3.5. Strategic Overview
        4. Purolite Corp
         4.1. Company Overview
         4.2. Product Portfolio
         4.3. SWOT Analysis
         4.4. Financial Overview
         4.5. Strategic Overview
        5. Danaher Corp
         5.1. Company Overview
         5.2. Product Portfolio
         5.3. SWOT Analysis
         5.4. Financial Overview
         5.5. Strategic Overview
        6. Bio-Rad Labs????????
         6.1. Company Overview
         6.2. Product Portfolio
         6.3. SWOT Analysis
         6.4. Financial Overview
         6.5. Strategic Overview

  • 16.   Pre and Post COVID-19 Impact

    •   1. Positive influence on the healthcare industry
        2. The financial disruption of the manufacturing sector
        3. Impact of COVID-19 on emerging companies
        4. Significant mandates in the healthcare regulations initiated by
                  administrations
        5. The overall economic slowdown of the developing and developed nations

  • 17.   FutureWise SME Key Takeaway Points for Client

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