Overview


According to FutureWise analysis the market for Oligonucleotide Synthesis in 2023 is US$ 9.01 billion, and is expected to reach US$ 31.68 billion by 2031 at a CAGR of 17.00%.

An oligonucleotide is a short chain of nucleotides that make up DNA or RNA molecules. It typically consists of between 10 and 100 nucleotides and can be designed to have a specific sequence and structure. Oligonucleotide synthesis is the process of artificially creating these short sequences of nucleotides in a laboratory. The process involves the chemical synthesis of nucleotide monomers that are then joined together to create the desired oligonucleotide sequence. There are several techniques used for oligonucleotide synthesis, including solid-phase synthesis, enzymatic synthesis, and microarray synthesis.

Oligonucleotide synthesis has a wide range of applications in various fields, including medicine, biotechnology, and research. One of the primary uses of oligonucleotide synthesis is in drug discovery. Synthetic oligonucleotides are being used as therapeutics to target specific disease-causing genes and proteins. They can be designed to bind to specific RNA or DNA molecules and inhibit their function, offering a more precise and targeted approach to treating disease than traditional small-molecule drugs. Oligonucleotide-based therapeutics are being developed for various diseases, including cancer, genetic disorders, and infectious diseases. In addition, oligonucleotide synthesis is used in molecular diagnostics, allowing for the early detection and diagnosis of diseases. Synthetic oligonucleotides can be used as probes for detecting specific DNA or RNA sequences in clinical samples, enabling the identification of genetic mutations and pathogens.

FutureWise Market Research has published a report that provides an insightful analysis of Oligonucleotide Synthesis Market trends that are affecting the overall market growth. This report will provide a detailed analysis of market share, regional insights, and competitor analysis that includes stature of key manufacturers operational in this industry. By the end of the forecast period FutureWise research analysts projects that Oligonucleotide Synthesis Market will experience a significant growth.

According to the analysis done, this report will help understand the information referring to the total valuation held by this industry. Additionally, this report will help in understanding the growth opportunities held by various segments of this market, further assist in making better strategic and expansion decisions by key stakeholders of an organization.
  • Danaher Corporation
  • Thermo Fisher Scientific, Inc.
  • Merck KGaA
  • LGC Limited
  • Maravai Life Sciences
  • Agilent Technologies, Inc.
  • Biogen Inc.
  • Sarepta Therapeutics, Inc.
  • Eurofins Scientific 
  • Kaneka Corporation
  • Biolytic Lab Performance Inc.
  • Microsynth Ag

(Note: The list of the major players will be updated with the latest market scenario and trends)

Recent developments by key players in Oligonucleotide Synthesis Market:

  • In July 2022, A newly constructed large-scale oligonucleotide and peptide production plant was established in the Changzhou location of WuXi STA, a division of WuXi AppTec. This new launch expands the company's capacity and competence to address the rapidly expanding client demand for oligonucleotide and peptide therapies.

The oligonucleotide synthesis market is a rapidly growing segment of the life sciences industry, driven by increasing demand for synthetic nucleotides for use in applications such as drug discovery, gene editing, and molecular diagnostics. One of the primary drivers of the oligonucleotide synthesis market is the increasing use of oligonucleotides in drug discovery and development. Synthetic oligonucleotides are being used as therapeutics to target specific disease-causing genes and proteins and as tools for gene editing and gene regulation. With the increasing focus on precision medicine and personalized therapies, the demand for synthetic oligonucleotides is expected to continue to grow. In addition, the growing demand for molecular diagnostics is driving the growth of the oligonucleotide synthesis market. Synthetic oligonucleotides are being used as probes for detecting specific DNA or RNA sequences in clinical samples, enabling the early detection and diagnosis of diseases. As the need for rapid and accurate molecular diagnostics increases, the demand for synthetic oligonucleotides is also expected to increase. Moreover, the increasing demand for high-throughput sequencing and synthetic biology is fueling the growth of the oligonucleotide synthesis market. Synthetic oligonucleotides are being used as building blocks for creating synthetic genes, genomes, and biological pathways, enabling the development of new biotechnologies and bio-based materials. Furthermore, the development of new technologies for oligonucleotide synthesis, such as microarray synthesis, solid-phase synthesis, and enzymatic synthesis, is driving the growth of the market. These technologies enable the efficient and cost-effective synthesis of large numbers of oligonucleotides with high purity and quality.

However, the oligonucleotide synthesis market faces several challenges, including the high cost of oligonucleotide synthesis, the need for specialized expertise, and the complex regulatory landscape for oligonucleotide-based therapeutics and diagnostics.

By Product

  • Oligonucleotide-based Drugs
  • Synthesized Oligonucleotides
  •  By Product
    •   Primers
    •   Probes
    •   DNA Oligos
    •   RNA Oligos
    •   Other Synthesized Oligos
  • By Type
    •   Customized Oligos
    •   Predesigned Oligos
  • Reagents
  • Equipment

By Application

  • Research Applications
    •   PCR
    •   Sequencing
    •   Other Research Applications
  • Diagnostic Applications

By Type 

  • Antisense Oligonucleotide-based Therapies
  • RNAi Oligonucleotide-based Therapies
  • CpG Oligonucleotide-based Therapies

By Disease Type 

  • Neurological Disorders
  • Infectious Diseases
  • Other Diseases

By End User

  • Hospitals
  • Pharmaceutical & Biotechnology Companies
  • Diagnostic Laboratories
  • CROs and CMOs
  • Academic Research Institutes

By Region

  • North America
  • Europe
  • Asia Pacific
  • Latin America
  • Middle East & Africa

This market research report also emphasis on factors affecting the growth rate in various regions listed above. A deep-down analysis of region will also be provided in the final version of this market which is based on conclusion of primary interviews and secondary data point gathered during the process.

By region, the market is segmented into North America, Latin America, Europe, Asia-Pacific, and Middle East & Africa. North America registered the highest share in the market in 2022. Over the projection period, North America is likely to dominate the market. The rising frequency of chronic and rare diseases among the population, increased R&D spending by companies, and the existence of important market competitors in the area are all factors contributing to market expansion. According to Cancer Facts and Figures 2022, there were over 1.9 million new cases of cancer in the United States in 2022. The rising cancer burden in the population increases the demand for sophisticated therapies, driving demand for oligonucleotide therapeutics and accelerating market expansion. Furthermore, according to IDF 2022 figures, around 2.9 million individuals in Canada had diabetes in 2021. This figure is expected to rise to 3.2 million by 2030 and 3.4 million by 2045, respectively. Thus, the predicted growth in the diabetic population in the nation increases the need for antisense oligonucleotides in the development of antidiabetic drugs since they can diminish the expression of disease-causing genes at the protein and RNA levels. This is expected to promote market growth throughout the forecast period.
  • Tier 1 players- established companies in the market with a major market share
  • Tier 2 players
  • Emerging players which are growing rapidly
  • New Entrants
  • Growth prospects
  • SWOT analysis
  • Key trends
  • Key data-points affecting market growth
  • To provide with an exhaustive analysis on the Oligonucleotide Synthesis Market By Product, By Application, By Type, By Disease Type, By End User and By Region.
  • To cater comprehensive information on factors impacting market growth (drivers, restraints, opportunities, and industry-specific restraints)
  • To evaluate and forecast micro-markets and the overall market
  • To predict the market size, in key regions— North America, Europe, Asia Pacific, Latin America and Middle East and Africa.
  • To record and evaluate competitive landscape mapping- product launches, technological advancements, mergers and expansions
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Table of Contents


  • 1.   Market Introduction
    •   1. Objectives of the Study
        2. Market Definition
        3. Market Scope
         3.1. Years Considered for the Study
         3.2. Market Covered
        4. Currency
        5. Limitations
        6. Stakeholders
  • 2.   Research Methodology
    •   1. Research Data
         1.1. Secondary Data
          1.1.1. Key Data from Secondary Sources
         1.2. Primary Data
          1.2.1. Key Data from Primary Sources
        2. Market Size Estimation
        3. Market Breakdown and Data Triangulation
        4. Assumptions for the Study
  • 3.   Executive Summary
    •   1. Market Outlook
        2. Segment Outlook
        3. Competitive Insights
  • 4.   Global Oligonucleotide Synthesis Market Variables, Trends and Scope

    •        1. Market Lineage Outlook
        2. Penetration and Growth Prospect Mapping
        3. Industry Value Chain Analysis
        4. Cost Analysis Breakdown
        5. Technology Overview
        6. Regulatory Framework
         6.1. Reimbursement Framework
         6.2. Standards and Compliances

  • 5.   Market Overview
    •   1. Market Dynamics
         1.1. Market Driver Analysis
          1.1.1. Increasing focus of Oligonucleotide Synthesis Market Companies on Brand Protection
          1.1.2. Untapped Opportunities in Emerging Regions
         1.2. Market Restraint Analysis
          1.2.1. High Cost Associated with Implementation of Predictive Analysis
         1.3. Industry Challenges
          1.3.1. Presence of Ambiguous Regulatory Framework
  • 6.   Global Oligonucleotide Synthesis Market Analysis Tools
    •   1. Industry Analysis - Porter’s
         1.1. Supplier Power
         1.2. Buyer Power
         1.3. Substitution Threat
         1.4. Threat from New Entrants
         1.5. Competitive Rivalry
        2. Pestel Analysis
         2.1. Political Landscape
         2.2. Environmental Landscape
         2.3. Social Landscape
         2.4. Technology Landscape
         2.5. Legal Landscape
        3. Major Deals And Strategic Alliances Analysis
         3.1. Joint Ventures
         3.2. Mergers and Acquisitions
         3.3. Licensing and Partnership
         3.4. Technology Collaborations
         3.5. Strategic Divestments
        4. Market Entry Strategies
        5. Case Studies
  • 7.   Global Oligonucleotide Synthesis Market, By Product Historical Analysis and Forecast 2023-2031 (USD Million)

    •   1. Oligonucleotide-based Drugs
        2. Synthesized Oligonucleotides
        3. By Product
         3.1. Primers
         3.2. Probes
         3.3. DNA Oligos
         3.4. RNA Oligos
         3.5. Other Synthesized Oligos
        4. By Type
         4.1. Customized Oligos
         4.2. Predesigned Oligos
        5. Reagents
        6. Equipment

  • 8.   Global Oligonucleotide Synthesis Market, By Application Historical Analysis and Forecast 2023-2031 (USD Million)

    •   1. Research Applications
         1.1. PCR
         1.2. Sequencing
         1.3. Other Research Applications
        2. Diagnostic Applications

  • 9.   Global Oligonucleotide Synthesis Market, By Type Historical Analysis and Forecast 2023-2031 (USD Million)

    •   1. Antisense Oligonucleotide-based Therapies
        2. RNAi Oligonucleotide-based Therapies
        3. CpG Oligonucleotide-based Therapies

  • 10.   Global Oligonucleotide Synthesis Market, By Disease Type Historical Analysis and Forecast 2023-2031 (USD Million)

    •   1. Neurological Disorders
        2. Infectious Diseases
        3. Other Diseases

  • 11.   Global Oligonucleotide Synthesis Market, By End User Historical Analysis and Forecast 2023-2031 (USD Million)

    •   1. Hospitals
        2. Pharmaceutical and Biotechnology Companies
        3. Diagnostic Laboratories
        4. CROs and CMOs
        5. Academic Research Institutes

  • 12.   North America Oligonucleotide Synthesis Market Analysis 2017-2022 and Forecast 2023-2031 (USD Million)

    •   1. Introduction
        2. Historical Market Size (USD Million) Analysis By Country, 2017-2022
         2.1. U.S.A
         2.2. Canada
         2.3. Mexico
        3. Market Size (USD Million) Forecast for North America 2023-2031

  • 13.   Latin America Oligonucleotide Synthesis Market Analysis 2017-2022 and Forecast 2023-2031 (USD Million)

    •   1. Introduction
        2. Historical Market Size (USD Million) Analysis By Country, 2017-2022
         2.1. Brazil
         2.2. Venezuela
         2.3. Argentina
         2.4. Rest of Latin America
        3. Market Size (USD Million) Forecast for Latin America 2023-2031

  • 14.   Europe Oligonucleotide Synthesis Market Analysis 2017-2022 and Forecast 2023-2031 (USD Million)

    •   1. Introduction
        2. Historical Market Size (USD Million) Analysis By Country, 2017-2022
         2.1. Germany
         2.2. U.K
         2.3. France
         2.4. Italy
         2.5. Spain
         2.6. Russia
         2.7. Poland
         2.8. Rest of Europe
        3. Market Size (USD Million) Forecast for Europe 2023-2031

  • 15.   Asia Pacific Oligonucleotide Synthesis Market Analysis 2017-2022 and Forecast 2023-2031 (USD Million)

    •   1. Introduction
        2. Historical Market Size (USD Million) Analysis By Country, 2017-2022
         2.1. Japan
         2.2. China
         2.3. India
         2.4. Australia and New Zealand
         2.5. ASEAN
         2.6. Rest of Asia Pacific
        3. Market Size (USD Million) Forecast for Asia Pacific 2023-2031

  • 16.   Middle East and Africa Market Analysis 2017-2022 and Forecast 2023-2031 (USD Million)

    •   1. Introduction
        2. Historical Market Size (USD Million) Analysis By Country, 2017-2022
         2.1. GCC
         2.2. Israel
         2.3. South Africa
         2.4. Rest of MEA
        3. Market Size (USD Million) Forecast for MEA 2023-2031

  • 17.   Market Share Analysis and Competitive Landscape
    •   1. Global Landscape - Key Players, Revenue and Presence
        2. Global Share Analysis - Key Players (Tier 1, Tier 2, Tier 3)
        3. Global Emerging Companies
        4. North America - Market Share Analysis and Key Regional Players
        5. Europe - Market Share Analysis and Key Regional Players
        6. Asia Pacific - Market Share Analysis and Key Regional Players
        7. Global Key Player - Growth Matrix
  • 18.   Company Profiles (Competition Dashboard, Competitors Deep Dive, Products Offered and Financial Layouts)

    •   1. Danaher Corporation
         1.1. Company Overview
         1.2. Product Portfolio
         1.3. SWOT Analysis
         1.4. Financial Overview
         1.5. Strategic Overview
        2. Thermo Fisher Scientific, Inc.
         2.1. Company Overview
         2.2. Product Portfolio
         2.3. SWOT Analysis
         2.4. Financial Overview
         2.5. Strategic Overview
        3. Merck KGaA
         3.1. Company Overview
         3.2. Product Portfolio
         3.3. SWOT Analysis
         3.4. Financial Overview
         3.5. Strategic Overview
        4. LGC Limited
         4.1. Company Overview
         4.2. Product Portfolio
         4.3. SWOT Analysis
         4.4. Financial Overview
         4.5. Strategic Overview
        5. Maravai Life Sciences
         5.1. Company Overview
         5.2. Product Portfolio
         5.3. SWOT Analysis
         5.4. Financial Overview
         5.5. Strategic Overview
        6. Agilent Technologies, Inc.
         6.1. Company Overview
         6.2. Product Portfolio
         6.3. SWOT Analysis
         6.4. Financial Overview
         6.5. Strategic Overview
        7. Biogen Inc.
         7.1. Company Overview
         7.2. Product Portfolio
         7.3. SWOT Analysis
         7.4. Financial Overview
         7.5. Strategic Overview
        8. Sarepta Therapeutics, Inc.
         8.1. Company Overview
         8.2. Product Portfolio
         8.3. SWOT Analysis
         8.4. Financial Overview
         8.5. Strategic Overview
        9. Eurofins Scientific
         9.1. Company Overview
         9.2. Product Portfolio
         9.3. SWOT Analysis
         9.4. Financial Overview
         9.5. Strategic Overview
        10.Kaneka Corporation
         10.1. Company Overview
         10.2. Product Portfolio
         10.3. SWOT Analysis
         10.4. Financial Overview
         10.5. Strategic Overview
        11.Biolytic Lab Performance Inc.
         11.1. Company Overview
         11.2. Product Portfolio
         11.3. SWOT Analysis
         11.4. Financial Overview
         11.5. Strategic Overview
        12.Microsynth Ag
         12.1. Company Overview
         12.2. Product Portfolio
         12.3. SWOT Analysis
         12.4. Financial Overview
         12.5. Strategic Overview

  • 19.   Pre and Post COVID-19 Impact

    •   1. Positive influence on the healthcare industry
        2. The financial disruption of the manufacturing sector
        3. Impact of COVID-19 on emerging companies
        4. Significant mandates in the healthcare regulations initiated by
                  administrations
        5. The overall economic slowdown of the developing and developed nations

  • 20.   FutureWise SME Key Takeaway Points for Client

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