Overview


According to the World Health Organization around 300 million people around the world have depression. At present switching antidepressants, increasing dosages, allowing more time for medications to work, augmented medication for other conditions, neuro-stimulation and psychotherapy are some of the ways for resistant depression treatment. However, burgeoning demand to counter the therapeutic challenge resulted in the emergence of innovative resistant depression treatment. Recently ketamine-based depression treatments are gaining preference as major biopharmaceutical companies receive a green signal from the Food and Drug Administration (FDA).

Rise in demand for antidepressant treatment due to increasing mental health issues. Burden on the healthcare system due to nonresponding patients to a combination of antidepressants. Ageing population as well as increased anxiety and depression syndrome in the millennials. Ineffectiveness of antidepressants due to an individual’s genetic composition. Exposure to addictive substances that prevent antidepressant medications to positively treat patients. Stigma related to depressive disorder treatments, patent expiration, fear of drug withdrawals, high cost, lack of substantial clinical trials to gauge the efficacy of resistant depression medicines contribute as the major restraints to the global resistant depression treatment market.

High prevalence of depression and mental disorders with substantial treatment resistance in Europe and North America are indicative of progressive growth of the market. Increasing awareness about mental health and related treatments are anticipated to create greater opportunities in the near future amongst the emerging nations in the Asia-Pacific and rest of the world.

  • Roche Holding
  • Johnson & Johnson
  • Merck &Co.
  • Novartis AG
  • Pfizer Inc.
  • Janssen Pharmaceuticals
  • Seelos Therapeutics
  • Bristol-Myers Squibb
  • GlaxoSmithKline plc

(Note: The list of the major players will be updated with the latest market scenario and trends)

Recent developments by key players in Resistant Depression Treatment Market:

Johnson & Johnson

  • In July 2024, Johnson & Johnson submitted a supplemental NDA seeking approval for Spravato as a monotherapy for treatment-resistant depression (TRD), potentially expanding its use beyond adjunctive therapy.
  • In January 2025, the FDA approved the first monotherapy for TRD, allowing treatment to begin without the need for an oral antidepressant baseline.

Roche 

Roche licensed the EVT-100 compound series, which includes EVT-101 and its successor EVT-103, to Evotec. Roche fully funded Phase II studies aimed at treating treatment-resistant depression (TRD). This collaboration, valued at over USD 300 million, highlights Roche's continued interest in NMDA-targeted therapies for difficult-to-treat depression.

By Drug Type

  • Selective serotonin reuptake inhibitors
  • Serotonin-norepinephrine reuptake inhibitors
  • Tricyclic antidepressants
  • Monoamine oxidase inhibitors
  • Atypical agents

By Distribution Channel

  • Hospital Pharmacies
  • Retail Pharmacies
  • Mail Order Pharmacies

By Region

  • North America
  • Latin America
  • Europe
  • Asia Pacific
  • Middle East and Africa

  • Tier 1 players- established companies in the market with a major market share
  • Tier 2 players
  • Emerging players which are growing rapidly
  • New Entrants

  • Growth prospects
  • SWOT analysis
  • Key trends
  • Key data-points affecting market growth

  • To provide with an exhaustive analysis on the Resistant Depression Treatment Market on the basis of Drug Type, Distribution Channel, and Region
  • To cater comprehensive information on factors impacting market growth (drivers, restraints, opportunities, and industry-specific restraints)
  • To evaluate and forecast micro-markets and the overall market
  • To predict the market size, in key regions (along with countries)—North America, Europe, Asia Pacific, Latin America, and the Middle East and Africa
  • To record evaluate and competitive landscape mapping- product launches, technological advancements, mergers and expansions

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Table of Contents


  • 1.   Market Introduction
    •   1. Objectives of the Study
        2. Market Definition
        3. Market Scope
         3.1. Years Considered for the Study
         3.2. Market Covered
        4. Currency
        5. Limitations
        6. Stakeholders
  • 2.   Research Methodology
    •   1. Research Data
         1.1. Secondary Data
          1.1.1. Key Data from Secondary Sources
         1.2. Primary Data
          1.2.1. Key Data from Primary Sources
        2. Market Size Estimation
        3. Market Breakdown and Data Triangulation
        4. Assumptions for the Study
  • 3.   Executive Summary
    •   1. Market Outlook
        2. Segment Outlook
        3. Competitive Insights
  • 4.  Resistant Depression Treatment Market Variables, Trends and Scope
    •   1. Market Lineage Outlook
        2. Penetration and Growth Prospect Mapping
        3. Industry Value Chain Analysis
        4. Cost Analysis Breakdown
        5. Technology Overview
        6. Regulatory Framework
         6.1. Reimbursement Framework
         6.2. Standards and Compliances

  • 5.  Resistant Depression Treatment Market Overview
    •   1. Market Dynamics
         1.1. Market Driver Analysis
          1.1.1. Increasing focus of Resistant Depression Treatment Companies on Brand Protection
          1.1.2. Untapped Opportunities in Emerging Regions
         1.2. Market Restraint Analysis
          1.2.1. High Cost Associated with Implementation of Predictive Analysis
         1.3. Industry Challenges
          1.3.1. Presence of Ambiguous Regulatory Framework

  • 6.  Resistant Depression Treatment Market Analysis Tools
    •   1. Industry Analysis - Porter’s
         1.1. Supplier Power
         1.2. Buyer Power
         1.3. Substitution Threat
         1.4. Threat from New Entrants
         1.5. Competitive Rivalry
        2. Pestel Analysis
         2.1. Political Landscape
         2.2. Environmental Landscape
         2.3. Social Landscape
         2.4. Technology Landscape
         2.5. Legal Landscape
        3. Major Deals And Strategic Alliances Analysis
         3.1. Joint Ventures
         3.2. Mergers and Acquisitions
         3.3. Licensing and Partnership
         3.4. Technology Collaborations
         3.5. Strategic Divestments
        4. Market Entry Strategies
        5. Case Studies

  • 7.  Resistant Depression Treatment Market, By Drug Type Historical Analysis and Forecast 2025-2033 (USD Million)
    •   1. Selective serotonin reuptake inhibitors
        2. Serotonin-norepinephrine reuptake inhibitors
        3. Tricyclic antidepressants
        4. Monoamine oxidase inhibitors
        5. Atypical agents

  • 8.  Resistant Depression Treatment Market, By Distribution Channel Historical Analysis and Forecast 2025-2033 (USD Million)
    •   1. Hospital Pharmacies
        2. Retail Pharmacies
        3. Mail Order Pharmacies

  • 9.  North America Resistant Depression Treatment Market Analysis 2018-2024 and Forecast 2025-2033 (USD Million)
    •   1. Introduction
        2. Historical Market Size (USD Million) Analysis By Country, 2018-2024
         2.1. U.S.A
         2.2. Canada
         2.3. Mexico
        3. Market Size (USD Million) Forecast for North America 2025-2033

  • 10.  Latin America Resistant Depression Treatment Market Analysis 2018-2024 and Forecast 2025-2033 (USD Million)
    •   1. Introduction
        2. Historical Market Size (USD Million) Analysis By Country, 2018-2024
         2.1. Brazil
         2.2. Venezuela
         2.3. Argentina
         2.4. Rest of Latin America
        3. Market Size (USD Million) Forecast for Latin America 2025-2033

  • 11.  Europe Resistant Depression Treatment Market Analysis 2018-2024 and Forecast 2025-2033 (USD Million)
    •   1. Introduction
        2. Historical Market Size (USD Million) Analysis By Country, 2018-2024
         2.1. Germany
         2.2. U.K
         2.3. France
         2.4. Italy
         2.5. Spain
         2.6. Russia
         2.7. Poland
         2.8. Rest of Europe
        3. Market Size (USD Million) Forecast for Europe 2025-2033

  • 12.  Asia Pacific Resistant Depression Treatment Market Analysis 2018-2024 and Forecast 2025-2033 (USD Million)
    •   1. Introduction
        2. Historical Market Size (USD Million) Analysis By Country, 2018-2024
         2.1. Japan
         2.2. China
         2.3. India
         2.4. Australia and New Zealand
         2.5. ASEAN
         2.6. Rest of Asia Pacific
        3. Market Size (USD Million) Forecast for Asia Pacific 2025-2033

  • 13.   Middle East and Africa Resistant Depression Treatment Market Analysis 2018-2024 and Forecast 2025-2033 (USD Million)
    •   1. Introduction
        2. Historical Market Size (USD Million) Analysis By Country, 2018-2024
         2.1. Saudi Arabia
         2.2. UAE
         2.3. South Africa
         2.4. Egypt
        3. Market Size (USD Million) Forecast for MEA 2025-2033

  • 14.  Market Share Analysis and Competitive Landscape
    •   1. Global Landscape - Key Players, Revenue and Presence
        2. Global Share Analysis - Key Players (Tier 1, Tier 2, Tier 3)
        3. Global Emerging Companies
        4. North America - Market Share Analysis and Key Regional Players
        5. Europe - Market Share Analysis and Key Regional Players
        6. Asia Pacific - Market Share Analysis and Key Regional Players
        7. Global Key Player - Growth Matrix

  • 15.  Company Profiles (Competition Dashboard, Competitors Deep Dive, Product Connected Devices and Disease Indication Portfolio, Financial Layouts)
    •   1. Roche Holding
         1.1. Company Overview
         1.2. Product Portfolio
         1.3. SWOT Analysis
         1.4. Financial Overview
         1.5. Strategic Overview
        2. Johnson & Johnson
         2.1. Company Overview
         2.2. Product Portfolio
         2.3. SWOT Analysis
         2.4. Financial Overview
         2.5. Strategic Overview
        3. Merck & Co.
         3.1. Company Overview
         3.2. Product Portfolio
         3.3. SWOT Analysis
         3.4. Financial Overview
         3.5. Strategic Overview
        4. Novartis AG
         4.1. Company Overview
         4.2. Product Portfolio
         4.3. SWOT Analysis
         4.4. Financial Overview
         4.5. Strategic Overview
        5. Pfizer Inc.
         5.1. Company Overview
         5.2. Product Portfolio
         5.3. SWOT Analysis
         5.4. Financial Overview
         5.5. Strategic Overview
        6. Janssen Pharmaceuticals
         6.1. Company Overview
         6.2. Product Portfolio
         6.3. SWOT Analysis
         6.4. Financial Overview
         6.5. Strategic Overview
        7. Seelos Therapeutics
         7.1. Company Overview
         7.2. Product Portfolio
         7.3. SWOT Analysis
         7.4. Financial Overview
         7.5. Strategic Overview
        8. Bristol-Myers Squibb
         8.1. Company Overview
         8.2. Product Portfolio
         8.3. SWOT Analysis
         8.4. Financial Overview
         8.5. Strategic Overview
        9. GlaxoSmithKline plc
         9.1. Company Overview
         9.2. Product Portfolio
         9.3. SWOT Analysis
         9.4. Financial Overview
         9.5. Strategic Overview

  • 16.   Pre and Post COVID-19 Impact
    •   1. Positive influence on the healthcare industry
        2. The financial disruption of the manufacturing sector
        3. Impact of COVID-19 on emerging companies
        4. Significant mandates in the healthcare regulations initiated by administrations
        5. The overall economic slowdown of the developing and developed nations
  • 17.   FutureWise SME Key Takeaway Points for Client

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